|LC Classifications||RC268.4 .F43 1990|
|The Physical Object|
|Pagination||xvi, 161 p. :|
|Number of Pages||161|
|LC Control Number||91185312|
Chromosomal disorder, any syndrome characterized by malformations or malfunctions in any of the body’s systems, and caused by abnormal chromosome number or constitution. Normally, humans have 46 chromosomes arranged in 23 pairs; the pairs vary in size and shape and are numbered by convention. Congenital Chromosome Aberrations and Tumour Predisposition. Gyorgy Fekete. (Pp ;,) Budapest: Akade-miai Kiado. In this book, the Hungarian author reviews some of the clinical and scientific publica-tions, published upto , concerning the association between genetic factors and malignant disease, with particular emphasisCited by: BOOK REVIEWS All titles reviewed here are available from the BMJ Bookshop, PO Box , London WC1H 9TE. Prices include postage in the UK and for members of the British Forces Overseas, but overseas customers should add 15% to the value of the order for postage and packing. Payment can be made by cheque in sterling drawn on a UK bank, or by. Numerical disorders. This is called aneuploidy (an abnormal number of chromosomes), and occurs when an individual either is missing a chromosome from a pair (monosomy) or has more than two chromosomes of a pair (trisomy, tetrasomy, etc.).. An example of trisomy in humans is Down syndrome, which is a developmental disorder caused by an extra copy of chromosome 21; the disorder is .
Lung cancers commonly have structural chromosome aberrations and aneuploidy, with many of them associated with carcinogenesis.. Gene amplification is a common mechanism of oncogenic activation in nonsmall cell lung cancer (NSCLC) involving genes such as MYC, EGFR, ERBB2, MET, PIK3CA, and FGFR1. Gene amplification is also associated with resistance to drugs, for instance, to epidermal . 4 Major Types of Chromosomal Aberrations ( Words) Some of the major types of Chromosomal aberrations are as follows: The arrangement and presence of many genes on a single chromosome provides a change in genetic information not only through change in chromosome number but also by a change in chromosome structure. Chromosome Aberrations - Science topic Abnormal number or structure of chromosomes. Many chromosome aberrations, but not all, are the cause of CHROMOSOME DISORDERS. Cancer may be defined as a progressive series of genetic events that occur in a single clone of cells because of alterations in a limited number of specific genes: the oncogenes and tumor suppressor genes. The association of consistent chromosome aberrations with particular types of cancer has led to the identification of some of these genes and the elucidation of their mechanisms of by:
Mortality is increased in all major sex-chromosome abnormalities (31,33,34,38–43), with hazard rates (or standardized mortality rates) ranging from to for KS, to XXX, to XYY and to for TS (Figure ).The specific causes for the increased mortality rates are described below. Rates of morbidity have been studied in TS and KS and have been found. A chromosomal aberration is an abnormality in the structure or number of chromosomes in an organism. Depending on the nature of the aberration, it can lead to severe birth defects, potentially including defects incompatible with somal aberrations can be diagnosed with the use of a karyotype, a visualization of an organism's complete set of chromosomes, where functional changes in. In the structural chromosomal aberrations, 5 cases had the inversions in chromosome 2, 7, 17, and Y. Chromosomal deletions in 6 cases and additions in 4 cases were analysed. The role of chromosome aberrations in evolution and human health is well recognized. Rating: (not Ritter S --Chromosome aberrations induced by high-LET carbon ions in radiosensitive and radioresistant tumour cells / Virsik --Transgenerational transmission of radiation- and chemically induced tumors and congenital anomalies in.